Photo of Dae Kim, Associate Scientist at the Hinda and Arthur Marcus Institute for Aging Research in Boston, MA

Dae Hyun Kim, MD, MPH, ScD

  • Associate Director & Senior Scientist, Hinda and Arthur Marcus Institute for Aging Research
  • Professor of Medicine, Harvard Medical School
  • Attending Geriatrician, Division of Gerontology, Beth Israel Deaconess Medical Center
  • Faculty

Dr. Kim is a geriatrician, researcher, and mentor, and serves as Associate Director of the Marcus Institute for Aging Research at Hebrew SeniorLife. He is committed to improving the care of older adults by incorporating frailty into clinical care, research, and population health.

Toward this mission, Dr. Kim founded and directs the Frailty Research Center at the Marcus Institute for Aging Research at Hebrew SeniorLife. Funded by grants from the National Institute on Aging, Harvard Catalyst, the Medical Foundation, and the John A. Hartford Foundation, his research aims to enable clinicians and health care systems to deliver clinical care and population health management tailored to an individual’s frailty level.

As a Beeson scholar, Dr. Kim developed the claims-based frailty index (CFI), an algorithm that estimates frailty using administrative claims data such as Medicare data. The CFI is now widely used by epidemiologists and health services researchers to measure frailty at a population scale. Dr. Kim served on the Project Advisory Task Force for the Office of the Assistant Secretary for Planning and Evaluation at the U.S. Department of Health and Human Services for the initiative "Validating and Expanding Claims-Based Algorithms of Frailty and Functional Disability for Value-Based Care and Payment." Using the CFI, his research evaluates how the benefits and harms of medications, surgical procedures, and care models vary by frailty level.

To translate frailty into clinical practice, Dr. Kim has developed the Comprehensive Geriatric Assessment-Based Frailty Index (also known as the Senior Health Calculator), an online tool that has been incorporated into the electronic medical records at Beth Israel Deaconess Medical Center. He also created eFrailty.org, a web-based platform hosting 15 validated frailty assessment tools and calculators, to make frailty assessment accessible to clinicians and researchers. These efforts have supported multiple quality improvement initiatives, integrated frailty assessment into fellowship education, and increased the use of frailty-informed decision-making and prognostic discussions with patients and families.

Clinically, Dr. Kim provides preoperative frailty assessment for medically complex older adults undergoing transcatheter aortic valve replacement in the Senior Health Practice at Beth Israel Deaconess Medical Center.

Dr. Kim has mentored more than 50 early-career investigators, including multiple recipients of National Institutes of Health career development awards. He is the recipient of a K24 Mid-career Investigator Award from the National Institute on Aging. He teaches and mentors students and trainees at Harvard Medical School, the Harvard Geriatrics Medicine Fellowship, and the Harvard T. H. Chan School of Public Health, and lectures regularly on frailty assessment in the Harvard Annual Review of Geriatric Medicine course. His contributions to education and mentorship have been recognized with Mentor of the Year Awards (2013, 2020), and the Educator of the Year Award (2022) from the Harvard Geriatric Medicine Fellowship, and the A. Clifford Barger Excellence in Mentoring Award from Harvard Medical School (2024).

Dr. Kim serves as an Associate Editor for the Journals of Gerontology Medical Sciences, is a member of the American Geriatrics Society Research Methods subcommittee, and serves on the editorial board of the Journal of the American Geriatrics Society. His contribution to the field has been recognized with several honors, including the 2017 American Geriatrics Society Junior Investigator of the Year Award, 2023 American Geriatrics Society Thomas and Catherine Yoshikawa Outstanding Scientific Achievement for Clinical Investigation Award, and the election to the American Society for Clinical Investigation in 2024.

Yonsei University     MD     02/2001     Medicine     Seoul, Korea

Johns Hopkins Bloomberg School of Public Health      MPH     05/2005     Epidemiology     Baltimore, MD

Thomas Jefferson University Hospital     06/2008     Internal Medicine     Philadelphia, PA

Beth Israel Deaconess Medical Center     06/2010     Geriatric Medicine     Boston, MA

Harvard T. H. Chan School of Public Health     ScD     05/2014     Epidemiology     Boston, MA

2006     The American Medical Association Foundation Seed Grant

2007     Young Investigator Award, AHA Quality of Care and Outcomes Research Meeting

2007     Winner in Research Abstract, ACP Southeast Pennsylvania Meeting

2008     Winner in Research Abstract, ACP National Meeting

2008     The Kowlessar Award in General Internal Medicine, Jefferson Medical College

2008     Winner in Research Abstract, ACP Massachusetts Meeting

2009     Winner in Research Abstract, ACP Massachusetts Meeting

2010     Emma Gildersleeve Lane Scholarship, Harvard University

2013     Mentor of the Year Award, Harvard Geriatric Medicine Fellowship

2016     Best Poster Award, American Geriatrics Society Annual Meeting

2017     Outstanding Junior Investigator of the Year Award, American Geriatrics Society

2020     Presidential Best Abstract Award, American Geriatrics Society Annual Meeting

2020     Mentor of the Year Award, Harvard Geriatric Medicine Fellowship

2022     Educator of the Year Award, Harvard Geriatric Medicine Fellowship

2023     Thomas and Catherine Yoshikawa Outstanding Scientific Achievement for Clinical Investigation Award, American Geriatrics Society

2024     Elected Member of the American Society for Clinical Investigation

2024     A. Clifford Barger Excellence in Mentoring Award, Harvard Medical School

01HL161697           (KRAMER, DANIEL BRUCE)                    Jul 15, 2022 - Jun 30, 2026
NIH
The Prospective Investigation of Palliative and End-of-Life ExpeRiences with ICDs (PIPER-ICD) Study
Role: Co-Investigator


R01AG081412           (LIN, JOSHUA K)                    Aug 1, 2023 - Apr 30, 2027                                                 NIH
A targeted analytical framework to optimize posthospitalization delirium pharmacotherapy in patients with Alzheimers disease and related dementias
Role: Co-Investigator


RF1AG090405          (LIN, JOSHUA K)                    Sep 15, 2025 - Sep 14, 2029
NIH
Optimizing validity of comparative effectiveness research in Alzheimer's disease and related dementias using large language models
Role: Co-Investigator


R01AG081268           (LIN, JOSHUA K)                    Sep 1, 2023 - May 31, 2027
NIH
Deprescribing antipsychotics in patients with Alzheimers disease and related dementias and behavioral disturbance in skilled nursing facilities
Role: Co-Investigator


K24AG073527           (KIM, DAE HYUN)                    Jul 1, 2022 - Jun 30, 2027
NIH
Mid-Career Mentoring Award For Patient-Oriented Research in Frailty and Health Outcomes
Role: Principal Investigator

Research Areas

Learn more about the areas of research where Dr. Kim focuses.

A string of computer code is reflected in the glasses of a researcher at the Marcus Institute for Aging in Boston, MA.

Data Science and Technology

The Marcus Institute includes a biostatistics and data sciences faculty who collaborate with investigators to design and conduct clinical trials and observational studies in aging.

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A scene of a hospital floor at Hebrew Rehabilitation Center in Boston, MA, with a nurse standing and working on a computer in the background and a blood pressure monitor in the foreground.

Health Care Services and Policy

The Marcus Institute seeks to effect change in policies that impact the care of older adults by identifying age-related conditions that have an outsized impact on health care utilization and costs, while developing interventions that mitigate the issues.

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A close-up shot at two hands holding a syringe that is inserted in a vial of medication.

Medication

Marcus Institute researchers are examining the relationship between medicine and adverse health outcomes such as falls, injuries, and treatment side effects among older people.

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A research subject at the Marcus Institute for Aging Research stands on a measuring platform with a computer read-out reflected on the wall behind.

Physical Health and Function

Through the Marcus Institute’s research we are learning how older adults can maintain independence and quality of life.

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Current Projects

View Dr. Kim's current projects. 

Deprescribing antipsychotics in patients with Alzheimer’s disease and related dementias and behavioral disturbance in skilled nursing facilities

The research aims to determine the health outcomes of different deprescribing strategies of antipsychotics used for behavioral and psychological symptoms of dementia in a skilled nursing facility. 

R01 AG081268 

Co-Investigator

Applications of Claims-Based Frailty Index to Advance Evidence for Frailty-Guided Decision-Making

This research aims to generate evidence needed for frailty-guided clinical care and
population health management by applying a claims-based frailty index to routine health care databases, including patients with Alzheimer’s Disease and Related Dementias.
NIH R01AG071809

Principal Investigator

Mid-Career Mentoring Award For Patient-Oriented Research in Frailty and Health Outcomes

This project aims to develop a mentoring program in frailty research for early-stage and new investigators; conduct high-quality research to determine heterogeneity of treatment effect by frailty for a broad range of medical and surgical interventions; and enhance PI's new research skills, mentoring capacity, and leadership.

K24 AG073527

Principal Investigator

A Targeted Analytical Framework to Optimize Post-Hospitalization Delirium Pharmacotherapy in Patients with Alzheimer’s Disease and Related Dementias

This research aims to compare continuation vs. different discontinuation strategies of antipsychotic medications in persons living with dementia. 

R01 AG081412

Co-Investigator

Evaluation of CMS Transitional Care and Chronic Care Management Services: Bridging the Gap and Maximizing Potential

The research aims to evaluate the effectiveness of the CMS Transitional Care Management and Chronic Care Management and develop strategies to increase adoption of these services. 

NIH R56 AG084578  

09/26/2024 – 08/31/2026

 

Principal Investigators

Utilization and Clinical Outcomes of Left Atrial Appendage Occlusion in Older Adults with Atrial Fibrillation and Frailty

The research aims to evaluate the effectiveness and safety of left atrial appendage occlusion device compared with direct oral anticoagulants in older adults with atrial fibrillation. 

R01 HL175560  

Principal Investigator

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