Photo of Sharon Inouye, Senior Scientist at the Hinda and Arthur Marcus Institute for Aging Research in Boston, MA

Sharon K. Inouye, MD, MPH

  • Senior Scientist
  • Milton and Shirley F. Levy Family Chair
  • Professor of Medicine, Harvard Medical School and Beth Israel Deaconess Medical Center
  • Faculty

Sharon K. Inouye, MD, MPH, is Professor of Medicine at Harvard Medical School, and the Milton and Shirley F. Levy Family Chair and Director of the Aging Brain Center at the Hinda and Arthur Marcus Institute for Aging Research. She is the Editor-in-Chief of JAMA Internal Medicine.

Dr. Inouye has made a significant impact on health and medicine through her seminal research in cognitive disorders of aging, including delirium and dementia, and through her leadership in health innovation. She has combined her clinical acumen with expertise in epidemiology, public health, and public policy to revolutionize the way we provide clinical care for older adults. She created the Confusion Assessment Method (CAM), translated into >20 languages and the most widely used delirium tool worldwide.

She developed an innovative approach to prevent delirium and functional decline in hospitalized older persons, the Hospital Elder Life Program (HELP), which has influenced how hospital care is provided worldwide.  

As a preeminent physician-scientist, Dr. Inouye has been continuously funded by the National Institutes of Health since 1989. She has held >90 grants, including a current >$13 million NIH-P01 grant and a >$10 million PCORI contract. She has published >400 articles, many in the highest impact journals (H-index =115), named by Thomson Reuters ScienceWatch as one of the World’s Most Influential Scientific Minds of the Decade, and Best Female Scientists in the World 2022 Ranking by Research.com.

She is a sought-after advisor, serving on National Advisory Council on Aging (NIA Council, 2023-2027); Board on Health Care Services, National Academies of Sciences, Engineering, and Medicine (NASEM), 2019-2026; Committee on Improving the Representation of Women and Underrepresented Minorities in Clinical Trials, NASEM, 2021-2022; and President’s Advisory Council, National Academy of Medicine Grand Challenge in Healthy Longevity, 2018-present. She has served on numerous workshops and committees for NASEM. She served as Associate Editor for JAMA Network Open from 2020-2023.

Among her many honors and recognitions are the Leonard Tow Humanism in Medicine Award from the Arnold P. Gold Foundation (2005), the Henderson Award from the American Geriatrics Society (2013), the M. Powell Lawton Award from the Gerontological Society of America (2015), Honorary Fellow of the American Academy of Nursing (2018), PBS-Next Avenue Influencer of Aging (2020), and the American College of Physicians John Phillips Memorial Award for Outstanding Work in Clinical Medicine (2023). She is an elected member of the American Society of Clinical Investigation (ASCI), the Association of American Physicians (AAP) and the National Academy of Medicine (NAM).

A dedicated teacher and mentor, she has individually mentored over 120 research trainees. Board-certified in internal medicine and geriatric medicine, she has dedicated her career to serving vulnerable and underserved older and homeless populations.

View an updated publication list

Learn more about delirium and access delirium resources at Delirium Central.

For information about AGS CoCare HELP.
 

Research Areas

Learn more about the areas of research where Dr. Inouye focuses.

A researcher at the Marcus Institute for Aging Research in Boston, MA studies MRI images of a human brain.

Brain Health

Through pioneering multidisciplinary research, the Marcus Institute is uncovering new answers to the challenges of Alzheimer’s disease, dementia, delirium, and other changes to the brain.

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A researcher at the Marcus Institute for Aging Research in Boston, MA holds a vial of blood.

Biomarkers and Genetics

As precision medicine enters the mainstream of clinical care, Marcus Institute researchers are working to advance the understanding of disease biomarkers and genetics.

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A string of computer code is reflected in the glasses of a researcher at the Marcus Institute for Aging in Boston, MA.

Data Science and Technology

The Marcus Institute includes a biostatistics and data sciences faculty who collaborate with investigators to design and conduct clinical trials and observational studies in aging.

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A scene of a hospital floor at Hebrew Rehabilitation Center in Boston, MA, with a nurse standing and working on a computer in the background and a blood pressure monitor in the foreground.

Health Care Services and Policy

The Marcus Institute seeks to effect change in policies that impact the care of older adults by identifying age-related conditions that have an outsized impact on health care utilization and costs, while developing interventions that mitigate the issues.

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A close-up shot at two hands holding a syringe that is inserted in a vial of medication.

Medication

Marcus Institute researchers are examining the relationship between medicine and adverse health outcomes such as falls, injuries, and treatment side effects among older people.

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A research subject at the Marcus Institute for Aging Research stands on a measuring platform with a computer read-out reflected on the wall behind.

Physical Health and Function

Through the Marcus Institute’s research we are learning how older adults can maintain independence and quality of life.

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Current Projects

View Dr. Inouye's current projects.

Better Assessment of Illness: Delirium Severity Measures for Persons with and without Dementia (BASIL)

This research aims to define delirium severity in patients with Alzheimer’s disease and related disorders, and develop new ways to measure delirium severity in participants both with and without dementia. 

NIH R01AG044518 

Principal Investigator

Hospital Elder Life Program (HELP) vs. Family-Augmented HELP (FAM-HELP) for Prevention of Delirium

Major Goals: To test the hypothesis that FAM-HELP will be superior to standard HELP for prevention of delirium and related complications, and for improving person- and family-centered outcomes.

Grant #: DE-2022C1-25666

Principal Investigator

Caffeine and Postoperative Neurocognitive Recovery

Major Goals: To test caffeine for mitigating risk of early postoperative delirium in older adults.

R01AG075005

Co-Investigator

NIDUS II: Advanced-Stage Development and Utilization of the NIDUS Research Infrastructure to Advance Interdisciplinary Aging Research in Delirium

Major Goals: To advance foundational research to develop more effective treatments for delirium by utilizing and expanding a research network, the Network for Investigation of Delirium: Unifying Scientists (NIDUS II), to bring together investigators across disciplines and institutions to conduct essential research to develop safe and effective treatments for delirium, and ultimately to improve outcomes for delirium in all older adults, particularly those with ADRD.

R33AG071744

DeliriumNetwork.org

Principal Investigator

The Network for Investigation of Delirium: Unifying Scientists (NIDUS)’s 9th-13th Annual Delirium Boot Camp: A Foundation for Future Exploration

Principal Investigator

READI SET GO: Researching Efficient Approaches to Delirium Identification—Sustaining Effective Translation to create Solicitation

To develop, translate, and sustain efficient approaches to delirium identification  

R01AG030618

Co-Investigator

Brain Vulnerability in Delirium and Alzheimer’s Disease and Related Dementias: The Intersection of Polygenic Risk and Inflammation

To probe whether polygenic risk scores of AD/ADRD moderate the association between inflammation and postoperative delirium, long-term cognitive decline, and incident AD/ADRD.

R01AG079864

Co-Investigator

AD/ADRD and biological aging proteomic signatures in the etiopathology of delirium and its associated long-term cognitive decline

To determine whether validated plasma proteomic signatures and clocks of aging of ADRD predict postoperative delirium and delirium with long-term cognitive decline.

R01AG051658

Co-Investigator

Skilled Nursing Facility Care at Home for Adults Discharged from the Hospital: A Randomized Controlled Trial

To develop a fully substitutive set of patient-tailored services that would allow for the provision of post-acute care at the level of a Post-Acute Facility to serve patients in their own homes.

Co-Investigator

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